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Pharmaceutical Technology

  A. Process Chemistry
  B. Formulations
  C. Biotechnology

bullet Pharmaceutical Management
bullet Pharmaceutics

The laboratories in the department are working in the areas of cell biology, biochemistry, immunology, molecular biology, microbiology, parasitology, cell culture, and membrane drug interaction. The department is actively pursuing research in the following areas.

  • Targeting signal transduction involved in microbial drug resistance

  • Identification of new target protein(s) in insulin mediated signal transduction and in insulin resistance

  • Enzyme drug interaction of medically important enzymes (Xanthine oxidase, HMG-CoA reductase etc.)

  • Membrane drug interaction for better understanding of tissue specific drug targeting

  • Proteomic analysis of yeast and mammalian cell to identify genes that regulate aging and knowledge based pathway building using informatics to understand set of circuits involved human longevity

  • Applied recombinant DNA technology for production of commercially important biochemicals

Medicinal Chemistry

The department is engaged in the following areas of research

Identification and validation of novel target sites for various therapeutic areas: Design and synthesis of new chemical entities as anticancer, antileishmanial, broad-spectrum antimalarial, antituberculosis, antihypertensive, antiinflammatory, antidiabatic, anti-viral compounds and multi-drug resistance reversal agents.

Asymmetric Synthesis: Development of methodologies for catalytic asymmetric synthesis-dynamic kinetic resolution, asymmetric protonation/ deprotonation, asymmetric epoxidation, asymmetric aziridation and asymmetric alkylation. Synthesis of chiral drugs .

Combinatorial Chemistry: Development of novel linkers and analytical protocols; generation of molecular libraries.

Peptide Synthesis: Synthesis of unnatural amino acids and their incorporation in the peptides of biological importance by using solution- and solid- phase synthesis protocols. Receptor binding studies on the TRH peptides.

Eco-friendly Processes: Development of new methodologies under solvent free condition, surface mediated reactions, microwave/ ultrasound assisted enhancement of reaction rates. Development of heterogeniuos catalysts. Use of ionic liquids as organo-catalysts- mechanistic investigation for rational design. Use of non-conventional reaction media- reaction in eater with or without any catalytic aid, mechanistic investigation of water catalysis for rational selection of newer reaction in water. Applications of the novel methods for synthesis of drugs, drug intermediates and new chemical entities for various therapeutic areas.

Computer Aided Drug Design: Molecular modeling methods based on molecular mechanics, Quantum mechanics. Analog based design of - Kinase, Phosphatase, Protease, HMG-CoA reductase, selective COX-2, selective PDE4 inhibitors and hemaglutinin of H1N1 virus. PPAR- g and Angiotensin receptor antagonist, Alzeimer dementia by 3D-QSAR, CoMFA, and docking methods.

Design and synthesis of PPARg agents.  3D QSAR, pharmacophore  mapping, virtual screening, molecular docking, de novo design of novel agents for PPARg activity.  Computer aided design of GSK3 inhibitors. Quantum chemical studies on the anti-diabetic drugs and leads -- sulfonylurea derivatives, DPPIV inhibitors, metformin analogs.

Design and synthesis of anti-malarial agents:  Quantum chemical methods in analyzing the reaction mechanism of synthesis of GTU (Guanylthiourea) derivatives as anti-malarial agents.  Synthesis of GTU derivatives for PfDHFR inhibition. Quantum chemical analysis of proguanil to cycloguanil conversion. Ab initio studies on the biurets, thiobiurets, etc. analogs of pyrimethamine.

Computational design of novel dedrimers units for anti-diabetic agent.

Computational prediction of SOM of substrates by Cytochromes.

Molecular Dynamic simulations (quantum as well as force field) to understand basics of drug action.

Natural Products

The departmental research activities are concentrated in the following areas:

1. Discovery of new chemical entities (NCEs) from natural products of terrestrial, microbial and marine origin in the following therapeutic areas:

  1. Discovery of anti-HIV, antimycobacterial and antiprotozoal mainly anti-leishmanial agents. Discovery and development of anti-diabetics, antioxidants and immunomodulating agents, adaptogens, anti-inflammatory agents, gynaecology and endocrine dysfunction studies and anticancer agents with apoptotic molecular basis.

  2. Development of in vitro testing models for screening of natural products, in the above mentioned therapeutic areas.

  3. Semisynthesis and synthesis of biologically active compounds alongwith generation of pseudonatural products.

2. Traditional Medicine development programmes: Standardization and quality control of herbal drugs and products.

  1. The overall objective and aim of this traditional medicine programme shall be to meet the demand of cost effective medications and biological agents from sustainable medicinal plant resources with the following steps:-

    • To lay down standards and effective quality controls on the Herbal Medicinal Products

    • To create databases for identification and authentication of materials with well defined botanical and phytochemical characteristics

    • To create libraries of marker/characterizing constituents for positive chemical identification of materials through chemoprofiling

    • To create quantitative standards for extracts and their formulations through chemo- and bio-profilings

    • To create standard protocols for establishing purity of materials, identification of adulterants, substitutes, pathogenic bacteria & fungi, heavy metals and pesticide residues

    • To develop dosage forms of the herbal products and their stability studies

    • To develop bioavailability protocols for herbal medicinal products with the help of biomarkers

    • Finally, to conduct clinical trials of the scientifically developed formulation and validate the traditional claims

  2. Understanding synergy between components of a medicinal plant, that have been described at a molecular level giving credence to the biomarker concepts apart from well understood chemical marker concepts

3. Process technology programmes: Development of chemical process technologies for important natural products involving isolation, semisynthesis or synthesis.

4. Other areas of interest:

  1. Agrotechniques for the development of commercially important medicinal plants with high active component

  2. Development of tissue/cell suspension cultures for production of secondary metabolites

  3. Development of analytical methods for phytochemicals

  4. Development of nutraceuticals with the clear cut structure-function relationships for quality dietary supplements

Pharmaceutical Analysis
The department is involved in the diversified activities, including active involvement in industrial research projects. The key areas of research are:
  • Physico-chemical characterization of new chemical entities
  • Forced degradation (stress testing) and stability kinetics studies
  • Preformualtion studies
  • Validated analytical method development including stability-indicating assays
  • Accelerated stability testing
  • Impurity profiling of drug substances
  • Preparation of degradation product standards
ADME QPrOmics Database (Department of Pharmaceutical Analysis in collaboration with University of Washington, USA is developing a data module of database named QPrOmics™ which is a Knowledge base crafted for enthusiasts and researchers pursuing the field of drug pharmacokinetics (PK) and pharmacodynamic (PD) and pharmacometricians in the drug development industry, regulatory and academia.)  
Pharmaceutical Management

A recent diversified expansion of the Institute is the Department of Pharmaceutical Management which has been created with a view to provide a specialized, high quality education as preparation for professional positions in pharmaceutical business and industry. The objectives of this course are to teach pharmaceutical management to the Pharmacy graduates to become the successful managers in pharmaceutical industry by applying the fundamentals of management. The department is actively engaged in Teaching, Research and Training and Development programmes related to the following:

  • To provide a specialized, high quality education as preparation for professional positions in pharmaceutical business and industry
  • To improve the quality, talent and skills of individuals to help them lead their lives as successful pharmaceutical management professionals
  • To explore the frontiers of knowledge from the industry through independent research, as well as in collaboration with other entities in pharmaceutical business or education having similar goals


  • A critical and integral component of our educational strategy is to help the Pharma industry with specially trained individuals without the limitations of a conventional curriculum and with abilities, attitudes and skills of a professional manager to serve effectively and efficiently in pharmaceutical industry
  • On-the job- training with the aim of helping the students to gain insights into the real, complex world of modern pharmaceutical business and observe human dynamics
  • Strong interaction with business and industry, particularly in the areas of teaching, seminars, training and placement in pharmaceutical industry
  • Substantial case inputs aimed at helping students to develop their decision making skills for modern Pharma business
Pharmaceutical Technology
A. Process Chemistry

A special feature of the Institute is the Department of Pharmaceutical Technology which has been created with a view to directly interact with industry. The department has a pilot plant associated with it for pilot-scale processing of bulk drugs and natural products. The department has build up facilities for scale up studies during development of technologies for bulk pharmaceutical chemicals and different dosage forms. The department is actively engaged and can collaborate in projects related to the following.

  • Process development for enantiomerically pure drugs
  • Chemical processing technology for natural products
  • Process for conducting eco-friendly reactions involving phase transfer catalysts, ionic liquids as alternate solvent media
  • Process for developing anti-diabetic compounds using novel technologies

Processes for the following APIs are available for licensing and other projects that have been completed:

  • Mefloquine HCl, Isosorbide-5-mononitrate, Artemether and Artesunate, S-Naproxen & S-Ibuprofen and Dicyclohexylcarbinol
  • Process for recycling levo enriched clopidogrel
  • Application of phase transfer methods in various production processes
  • Process for making chiral unnatural amino acids
  • Process for making Escitalopram from racemic citalopram
  • Process for making various chiral phase-transfer catalysts
  • Synthetic routes for making various tricyclic dual PPAEa/c agonists having antioxidant properties
  • Process for making novel 1,4-Naphthoquinones
  • Process for making levobupivacaine
  • Process for making 2-ethylhexyl 4-methoxycinnamate in ionic liquids
B. Formulations
  • Preformulation studies of new molecular entities
  • Prototype formulation development and product/process challenge studies on solid and liquid dosage forms
  • Solid state characterization of pharmaceuticals
  • Generation of polymorphs, pseudo-polymorphs and amorphous form; Characterization using thermal, spectroscopic, crystallographic (powder and single crystal) techniques; Solubility advantage; Thermodynamic characterization - van't Hoff plots; Effect of polymorphism on product performance; solid state transformations during pharmaceutical processing; regulatory implications
  • Generation of co - crystals to improve aqueous solubility of poorly water soluble drugs
  • High energy amorphous form - Generation; characterization using thermal, spectroscopic, crystallographic techniques; Thermodynamic parameters like enthalpy, entropy, specific heat; Kinetic characterization of the molecular mobility of amorphous systems using enthalpy relaxation studies, cocnept of fragility and fictive temperature; Stabilization of the amorphous systems using anti - plasticizer, specific molecular interactions, crystal growth inhibitors; Solubility advantage of amorphous syetms; Molecular interactions vis a vis stable crystalline form; Devitrification during storage and dissolution stage; Ternary amorphous dispersions to improve aqueous solubility
  • Improved powder properties using particle engineering and co-processing of pharmaceuticals; Study of compression behavior; Heckel's plots; Physico - technical properties
  • Reverse engineering of generic formulations to - propose quantitative formula, solid state characteristics of the API in the dosage form, information on manufacturing process; Concept of 'formulation equivalence' to develop bio-equivalent generic products
  • Improvements of oral bioavailability using lipidic systems
  • Intestinal permeability studies and permeation enhancement of drugs using excipeints
  • Stabilization of protein drugs during lyophilization
C. Biotechnology

The biotechnology unit of Pharmaceutical Technological Department has been set up with a view to create awareness in the field of pharmaceutical biotechnology. Biotechnology being an interdisciplinary subject and NIPER being an pharmaceutical institute, pharmaceutical biotechnology was thought to be an appropriate subject of teaching and research in this department. The main objective is to pertain training to the students on the different aspects of pharmaceutical biotechnology such as production of high value products though high cell density fermentation, to produce active intermediates through biocatalysis, downstream processing of biomolecules, etc. The unit has taken the initiative to start research activities in the field of biocatalysis to produce enantiomerically pure isomers intended to use as drugs and drug intermediates. The unit runs a full fledged M.Tech. programme in pharmaceutical biotechnology sponsored by the Department of Biotechnology (Govt. of India). The following projects are currently going on

  • Production of chiral precursor (S)-1-(2-thienyl) ethanol or (S)-N, N-dimethyl-3-hydroxy-3-(2-thienyl)-propanamine through microbial reduction and their use in the synthesis of chiral drug S (+)-Duloxetine
  • Cloning and expression of an acid phosphatase (PHYB) with high phytase activity in yeast
  • Purification and characterization of lipase/s for the synthesis of biologically active and enantiomerically pure isomers obtained through enzymatic kinetic resolution of racemates
  • Use of nitrilase, a biocatalyst, for the enzymatic kinetic resolution of racemic mixture of pharmaceutically active compounds to enantiomerically pure isomer
Pharmacology and Toxicology

Department of Pharmacology and Toxicology has the facilities to carry out pharmacological screening of NCEs. The department can enter into project collaborations in regulatory toxicological testing, viz., acute, sub-chronic and chronic toxicity testing. The departmental research activities are concentrated in the following areas:

  • Opioid tolerance, supersensitivity and dependence mechanisms
  • Role of different subtypes of angiotensin receptors in hypertension and diabetic vascular complications
  • Understanding the mechanisms of diabetic complication and development of NIDDM & insulin resistance models in rodents; screening of synthetic and natural products for their antidiabetic activity
  • Role of alpha adrenoceptors in benign prostatic hyperplasia
  • Understanding the molecular mechanisms involved in ischaemic stroke
  • Evaluation of novel neuroprotective approaches for the treatment of cerebral ischemia
  • Development of animal models of cerebral ischemia
  • Understanding the mechanisms of diabetic neuropathy
  • Role of adenosine receptors subtypes in diabetic neuropathic pain
  • Evaluation of various neuroprotective approaches in diabetic neuropathy
  • Screening of NCEs for antileismanial activity.
  • Development of rat model for Alzheimer's disease and screening of NCEs on learning and memory in rats
  • Production of monoclonal antibodies against Plasmodium yoelii nigeriensis antigens with the objective of characterization of protective antigens
  • Molecular mechanisms of protection, cytoadherence, immune evasion and red cell invasion in malaria
  • Biotherapeutics and chemotherapeutics evaluation of potential antimalarial, antitubercular, antileishmanial and antiamoebic agents in vitro and in vivo
  • Study of the opioids-induced bidirectional molecular signaling within the neuroimmune network with a view to develop new immunomodulators.
  • Histone modifications as targets for drug discovery
  • Molecular mechanism involved in toxicant and oxidative stress induced process of cell death

Technologies Available


Drug development has become increasingly complex, time consuming and expensive. As a result there is an increased focus on making clinically established drugs perform better therapeutically in terms of efficacy, safety and improved patient compliance by designing novel and patentable technologies or delivery systems. This has led to a paradigm shift in drug delivery technologies from conventional dosage forms to controlled release and sophisticated delivery systems. These systems are based on the concepts of biopharmaceutics and pharmacokinetic driven by pharmacodynamic activity and therapeutic needs. The emergence of the Biopharmaceutic Classification System (BCS) based on the two tenets of absorption namely solubility and permeability has further simplified drug development program form a regulatory perspective. About 20 drugs, which are not only of clinical significance but also, model drugs representing various classes were chosen by the department to carry out research and projects in the area of conventional and novel drug delivery systems, biopharmaceutics and pharmacokinetic evaluation, bioavailability and bioequivalence testing, preformulation, formulation development and stability testing.

The department of pharmaceutics is one of the key departments of the Institute. It is equipped with state of the art facilities to undertake research in drug development and delivery. More recently, the department has initiated research on Biomaterials and Nanotechnology. In the frontier area of Biomaterial research, the focus will be for synthesis and characterization of new biodegradable polymer, their formulations for various drug delivery systems, to improve surface biocompatibility of medical devices and their invitro/invivo evaluation. To strengthen our research potential, nanotechnolgy will be utilized to prepare effective carriers to deliver the drugs at diseases targets and effort will be taken to initiate gene delivery program in our department.

The department is presently engaged in research projects on:

  • Development and evaluation of peroral controlled release systems
  • Development and evaluation of buccal and transdermal drug delivery systems
  • Biopharmaceutic and pharmacokinetic studies including bioavailability and bioequivalence studies
  • In vitro and in vivo evaluation of conventional and new drug delivery systems
  • Biomaterials for novel drug delivery systems
  • Nano-biopharmaceutics: Focus on drug targeting and gene delivery
Pharmacy Practice

In 2002, a new course leading to the award of M. Pharm. (Pharmacy Practice) was started at NIPER, SAS Nagar. The three core areas identified for this department are Clinical, Hospital and Community Pharmacy. In a very short span of time, the department has made significant progress and has been able to evolve on the first two areas by developing a strong interface with three major hospitals in the region.

One of the missions of the department is to provide quality-teaching programs that will prepare the students for entry into all areas of professional pharmacy practice.
The department intends to promote research and service, demonstrating excellence in professional practice and outreach.

Currently, the emphasis is placed on principles of pharmacotherapy and practice management for the purpose of advancing quality cost-effective pharmaceutical care. The Department of Pharmacy Practice is committed to:

  • Development of long-term functional practice skills in its students, and others in the profession

  • Development and practice of systematic approach to identification and finding solutions of drug-related problems

  • Implementation of Good Pharmacy Practice Points for Clinical pharmacists and for clinical pharmacy educator

  • Research leadership in desired areas of excellence and developing areas especially pertaining to the rural health

  • Development of interdisciplinary research programs within the Institute and others schools of Pharmaceutical sciences in the country

  • Leadership in national, state and local professional associations and a strong role in developing future practice standards and models

  • Provision of the highest level of pharmaceutical services to the citizens of country

The department intends to grow into the following areas and looks forward to collaborate with external agencies

  • Promoting rational use of drugs. The department works in close coordination with the Delhi Society for Promotion of Rational use of Drugs (DSPRUD).

  • Research into the drug-related healthcare issues Identifying, monitoring and solving drug-related problems Establishment of clinical pharmacy services

  • Drug utilization reviews and cost containment issues in hospital pharmacy

  • Setting up of Patient counseling facilities in hospitals

  • Offering Continuing Professional Education (CPE) programs for all sections of the profession

In 2011, another new course leading to M.Pharm. (Clinical Research) was started and the department was entrusted to run this course. Upon successful completion of this course, the students are geared to get into any functional area of clinical research. They receive intensive training in medical writing, documentation, clinical data management, project management and complete a six-month project too.

For any further queries about these programs, please feel free to contact Prof. Pramil Tiwari, Professor & Head of the department through e-mail

Top Twenty FAQs <> {Join e-group "Pharmacy Practice India", Contact :}


Drug discovery research has become much more complex science requiring a multidisciplinary approach. Converging concepts of several disciplines such as molecular biology, chemistry, toxicology, pharmaceutical sciences and computational technology has become more than a trend in education. It has become a necessity for solving real-world problems. This course is designed to teach the new millennium drug discovery science to the pharmacy graduates to become the successful drug discovery scientist in pharmaceutical industry.

The objectives are,

  • To teach the science and art of "New Millennium Drug Discovery' for faster drug development.

  • To teach the information management and integration techniques in the field of Biology, Chemistry, Toxicology, Pharmaceutical sciences and Pharmacy practice.

  • To integrate diverse information into discovery knowledge by exploiting the advantages of emerging fields like bio-informatics, chemo-informatics, toxico-informatics, pharmacy-informatics, etc


  1. The center is equipped to carry out research and provide training in the advanced areas of genomics, proteomics, computational drug discovery techniques including bioinformatics, QSAR, Molecular Docking, pharmacophore mapping, chemoinformatics, computational ADME / Toxicity prediction methods, pharmaceutical informatics and medical informatics.
  2. The focus of this centre is on the practical applications of computer aided target identification, validation and drug-design, this centre is quite different from other academic centres where the focus is either on theoretical studies or on development of bioinformatic methods or on chemoinformatic methods.
Software Tools Developed by the Students
Training and Continuing Education Programs

In order to keep pharmacy professionals acquainted with the latest developments in the field of pharmacy, the institute conducts training programs from time to time. NIPER has been empanelled by Ministry of External Affairs, Government of India to conduct training programs on regulatory aspects in pharmaceutical sciences for the international delegations and also by Ministry of Health to conduct training programs for drug regulatory staff, government analysts and technical and analytical staff from SSIs. The institute can provide specialized training in the following areas:

  • cGMP/GLP, validation procedures in pharmaceutical industry
  • Standardisation of herbal products
  • Macro and micro-propagation of medicinal plants
  • Separation techniques
  • Modern analytical techniques for quality assurance
  • Impurity profiles of bulk pharmaceutical chemicals and their formulations
  • Degradation chemistry and stability testing of drugs and pharmaceuticals
  • Bioavailability and bioequivalence of pharmaceutical dosage forms
  • Documentation in pharmaceutical research, development and manufacturing
  • Recombinant DNA technology for drugs
  • Secretory proteins and biomass production through fermentation
  • Primary drug screenings
  • Regulatory toxicology
  • Synthesis and technology of chiral drugs
  • Scale up techniques in pharmaceutical industry
  • Development of eco-friendly processes
  • Generation of combinatorial libraries of small molecules
  • Computer aided drug design
  • Pharmaceutical project management
















Page Last Updated / Reviewed on: 26-October-2017

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